11/1/2022 0 Comments Lexapro insomnia helpNorepinephrine is a neurotransmitter that plays a role in attention, alertness, and blood pressure. Serotonin is a neurotransmitter that plays a role in mood, appetite, and sleep. This action increases the levels of these neurotransmitters in the brain. SNRIs work by blocking the reuptake of serotonin and norepinephrine in the brain. The first reason is that Lexapro is a serotonin-norepinephrine reuptake inhibitor (SNRI). There are several reasons why Lexapro may cause insomnia. Although Lexapro is effective for many people, it can also cause some side effects, including insomnia. It works by increasing the levels of serotonin, a chemical messenger in the brain, which helps to improve mood and relieve anxiety. Lexapro is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It is important to understand how Lexapro works to understand how it can cause insomnia. Insomnia can make it difficult to fall asleep or stay asleep and can lead to fatigue during the day. Insomnia is one of the most common side effects associated with Lexapro. While Lexapro is generally considered to be a safe and effective medication, it can cause some side effects, including insomnia. SSRIs work by increasing levels of serotonin in the brain, which can help to improve mood and alleviate anxiety. The active ingredient in Lexapro is escitalopram, which is a member of the selective serotonin reuptake inhibitor (SSRI) class of drugs. In the interim, from a clinical perspective, escitalopram appears to be beneficial for the treatment of sleep problems in MDD and GAD.Lexapro is a type of antidepressant that is often prescribed to treat anxiety and depression. In MDD, the rate of insomnia as an adverse event after escitalopram was higher than placebo, similar to SSRIs, and lower than SNRIs.Īdditional research assessing the comparative effects of antidepressants with polysomnography is needed. The same pattern was seen for the large proportion (67%-82%) of GAD patients reporting sleep problems at baseline (baseline HAM-A item 4 score ≥ 2). For patients with GAD (n = 2052) the treatment difference in sleep symptoms measured by HAM-A item 4 ("insomnia") was significantly in favor of escitalopram versus placebo (LOCF and MMRM ), but not different to paroxetine or venlafaxine. Sleep-related treatment-emergent adverse events were also compared across groups.įor patients with MDD (n = 5133), the treatment difference on MADRS item 4 ("reduced sleep") was significantly in favor of escitalopram versus placebo (LOCF and MMRM ), versus SSRIs (LOCF and MMRM ). Both last observation carried forward (LOCF) and repeated measurements (MMRM) were used to analyze the sleep item of the Montgomery Åsberg Depression Rating Scale (MADRS) or Hamilton Anxiety Rating Scale (HAM-A) after 8 weeks of treatment. First-line antidepressants, including the selective serotonin reuptake inhibitors (SSRIs) and serotonin noradrenaline reuptake inhibitors (SNRIs), may have different effects on sleep.ĭata from 22 randomized, controlled trials comparing escitalopram with SSRIs, SNRIs, or placebo in the treatment of adult MDD or GAD were included. Disturbed sleep is a key symptom in major depressive disorder (MDD) and generalized anxiety disorder (GAD).
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